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Article

Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.

Malaria journal - 8 Dec 2015

Nunes-Silva Sofia, Dechavanne Sébastien, Moussiliou Azizath, Pstrąg Natalia, Semblat Jean-Philippe, Gangnard Stéphane, Tuikue-Ndam Nicaise, Deloron Philippe, Chêne Arnaud, Gamain Benoît

Abstract excerpt

BACKGROUND: Malaria is still one of the most prevalent infectious diseases in the world. Sequestration of infected erythrocytes (IEs) is the prime mediator of disease. Cytoadhesion of IEs is mediated by members of the highly diverse Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). A restricted sub-set of var genes encoding for PfEMP1s possessing the domain cassettes DC8 and DC13 were found to bind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26646943
DOI: 10.1186/s12936-015-1008-5
PMCID: PMC4672576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.PMID 26646943Read ↗

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