Article
Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns.
BMC medical genetics - 17 May 2012
Ojurongbe Olusola, Ouf Eman Abou, Van Tong Hoang, Toan Nguyen L, Song Le H, Luz Paola R, Messias-Reason Iara J T, Nurjadi Dennis, Zanger Philipp, Kun Jürgen F J, Kremsner Peter G, Velavan Thirumalaisamy P
Abstract excerpt
BACKGROUND: Ficolin-2 coded by FCN2 gene is a soluble serum protein and an innate immune recognition element of the complement system. FCN2 gene polymorphisms reveal distinct geographical patterns and are documented to alter serum ficolin levels and modulate disease susceptibility. METHODS: We employed a real-time PCR based on Fluorescence Resonance Energy Transfer (FRET) method to genotype four functional SNPs...
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