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Article

Novel FCN2 Variants and Haplotypes are Associated with Rheumatic Heart Disease.

DNA and cell biology - 1 Oct 2021

Badarukhiya Jaydeep A, Tupperwar Nitin, Nizamuddin Sheikh, Mulpur Anil Kumar, Thangaraj Kumarasamy

Abstract excerpt

Ficolins are pattern recognition molecules that are involved in innate immune defense. Ficonin-2 (FCN2) has a specific affinity for lipoteichoic acid present in the cell wall of Streptococcus pyogenes, an etiological agent for rheumatic heart disease (RHD). We have estimated FCN2 serum levels and analyzed the functional variants of FCN2 in 400 RHD patients, 617 healthy controls, and 581 individuals belonged to...

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Identifiers

PMID: 34529517
DOI: 10.1089/dna.2021.0478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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