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Article

Polymorphisms in FCN genes and their influence on systemic lupus erythematosus susceptibility: a report from Western India.

ImmunoHorizons - 24 Nov 2025

Rai Kirti, Khatri Ridi, Jose Amrutha, Nadkar Milind, Rajadhyaksha Anjali, Konkar Harshada, Samant Trisha, Jaiswal Pooja, Dabholkar Kunal, Pawaskar Swapnal, Malik Aman, Parande Altaf, Bitla Gauthami, Tapase Prashant, Padwal Vijay, Madkaikar Manisha, Pradhan Vandana D

Abstract excerpt

Ficolins, encoded by FCN genes, are key pattern recognition molecules of the lectin complement pathway involved in immune complex clearance, a process often impaired in systemic lupus erythematosus (SLE). Genetic polymorphisms in FCN genes may influence disease susceptibility. However, their functional significance in SLE remains unclear. The present study aimed to investigate the association of selected FCN gene...

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Source

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Identifiers

PMID: 41285030
DOI: 10.1093/immhor/vlaf064
PMCID: PMC12643474

Genes

FCN2
FCN3
FCN1

Provenance

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