The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels.

doi:10.1111/j.1365-3083.2007.01915.x

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Article

The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels.

Scandinavian journal of immunology - 1 Apr 2007

Munthe-Fog L, Hummelshøj T, Hansen B E, Koch C, Madsen H O, Skjødt K, Garred P

Abstract excerpt

Ficolin-2 (L-ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter-individual variation in serum appears to be under genetic control. To validate and extend this finding, we developed a sandwich ELISA for detection of human Ficolin-2 in serum samples and identified FCN2 genotypes with a Taq Man-based minor groove binder assay and by...

Topics

Animals
Antibodies, Monoclonal
Antibody Specificity
Base Sequence
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Haplotypes
Humans
Lectins
Mice
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Ficolins

Source

Open in PubMed

Identifiers

PMID: 17386030
DOI: 10.1111/j.1365-3083.2007.01915.x

Genes

FCN2
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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