Article
Polymorphisms of the FCN2 Gene 3'UTR Region and Their Clinical Associations in Preterm Newborns.
Frontiers in immunology - 1 Jan 2021
Świerzko Anna S, Jarych Dariusz, Gajek Gabriela, Chojnacka Karolina, Kobiela Paulina, Kufelnicka-Babout Maja, Michalski Mateusz, Sobczuk Katarzyna, Szala-Poździej Agnieszka, Matsushita Misao, Mazela Jan, Domżalska-Popadiuk Iwona, Kilpatrick David C, Kalinka Jarosław, Sekine Hideharu, Cedzyński Maciej
Abstract excerpt
Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3'-untranslated region (3'UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3'UTR...
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