Article
Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease.
Clinical and experimental immunology - 1 Sept 2009
Messias-Reason I J, Schafranski M D, Kremsner P G, Kun J F J
Abstract excerpt
Ficolins are pattern-recognition proteins involved in innate immunity, which upon binding to their specific pathogen-associated molecular patterns on the microbial surfaces trigger the immune response either by binding to collectin cellular receptors or by initiating the complement lectin pathway. In humans, three ficolin genes have been identified, which encode ficolin-1 (M-ficolin), ficolin-2 (L-ficolin) and...
Topics
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- Chronic Disease
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Lectins
- Logistic Models
- Male
- Middle Aged
- Polymorphism, Single Nucleotide