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Article

Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease.

Clinical and experimental immunology - 1 Sept 2009

Messias-Reason I J, Schafranski M D, Kremsner P G, Kun J F J

Abstract excerpt

Ficolins are pattern-recognition proteins involved in innate immunity, which upon binding to their specific pathogen-associated molecular patterns on the microbial surfaces trigger the immune response either by binding to collectin cellular receptors or by initiating the complement lectin pathway. In humans, three ficolin genes have been identified, which encode ficolin-1 (M-ficolin), ficolin-2 (L-ficolin) and...

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Source

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Identifiers

PMID: 19664148
DOI: 10.1111/j.1365-2249.2009.03975.x
PMCID: PMC2745034

Genes

FCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease.PMID 19664148Read ↗

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Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns.Semantic proximity Read ↗

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2Semantic proximity Read ↗

Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.Semantic proximity Read ↗

Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns.Semantic proximity Read ↗

MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement.Semantic proximity Read ↗

Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.Semantic proximity Read ↗

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