Article
Limited effect on NS3-NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease.
The Journal of general virology - 1 Aug 2012
Ahlén Gustaf, Chen Antony, Roe Barbara, Falkeborn Tina, Frelin Lars, Hall William W, Sällberg Matti, Söderholm Jonas
Abstract excerpt
It has been well established that immunological escape mutations within the hepatitis C virus genotype (gt) 1a non-structural (NS) 3/4A protease are partly prevented by a reduction in viral protease fitness. Surprisingly little is known about whether similar mutations affect proteases from other genotypes. In the present study, we assessed both the HLA-A2-restricted CTL response and gt3a NS3/4A protease fitness....
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