Article
Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.
Gut - 1 Nov 2011
Fitzmaurice Karen, Petrovic Danijela, Ramamurthy Narayan, Simmons Ruth, Merani Shazma, Gaudieri Silvana, Sims Stuart, Dempsey Eugene, Freitas Elizabeth, Lea Susan, McKiernan Susan, Norris Suzanne, Long Aideen, Kelleher Dermot, Klenerman Paul
Abstract excerpt
BACKGROUND AND AIMS: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has been described, and the aim of this study was to define the protective nature of the associated...
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