Article
Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.
Journal of virology - 1 Dec 2008
Salloum Shadi, Oniangue-Ndza Cesar, Neumann-Haefelin Christoph, Hudson Laura, Giugliano Silvia, aus dem Siepen Marc, Nattermann Jacob, Spengler Ulrich, Lauer Georg M, Wiese Manfred, Klenerman Paul, Bright Helen, Scherbaum Norbert, Thimme Robert, Roggendorf Michael, Viazov Sergei, Timm Joerg
Abstract excerpt
The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism for T-cell failure. HLA-B*08 was recently identified as one HLA class I allele associated with spontaneous clearance of HCV replication....
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