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Article

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.

Journal of virology - 1 Jan 2016

Walker Andreas, Skibbe Kathrin, Steinmann Eike, Pfaender Stephanie, Kuntzen Thomas, Megger Dominik A, Groten Svenja, Sitek Barbara, Lauer Georg M, Kim Arthur Y, Pietschmann Thomas, Allen Todd M, Timm Joerg

Abstract excerpt

UNLABELLED: Antiviral CD8(+) T cells are a key component of the adaptive immune response against HCV, but their impact on viral control is influenced by preexisting viral variants in important target epitopes and the development of viral escape mutations. Immunodominant epitopes highly conserved across genotypes therefore are attractive for T cell based prophylactic vaccines. Here, we characterized the CD8(+) T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26446603
DOI: 10.1128/JVI.01993-15
PMCID: PMC4702586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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