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Article

A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: relation to recognition by cytotoxic T lymphocytes.

The Journal of infectious diseases - 15 Dec 2006

Soderholm Jonas, Sallberg Matti

Abstract excerpt

The hepatitis C virus nonstructural (NS) 3/4A protease sequence is highly conserved for reasons not fully understood. We determined the protease activity in 181 NS3/4A gene products in which each protease residue was replaced by alanine or glycine. Unexpectedly, most (87%) protease residues could be replaced and protease activity would be retained. Using these data, we were able to identify a human leukocyte...

Read the complete abstract on PubMed

Topics

3C Viral Proteases
Amino Acid Sequence
Amino Acid Substitution
Animals
Cysteine Endopeptidases
Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

Genetic Variation

HLA-A2 Antigen

Hepacivirus

Hepatitis C

Humans

Mice

Mice, Transgenic

Molecular Sequence Data

Mutagenesis

Species Specificity

Spleen

Source

Identifiers

PMID: 17109345
DOI: 10.1086/509513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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