Article
Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals.
Retrovirology - 19 Nov 2015
Sakai Keiko, Chikata Takayuki, Brumme Zabrina L, Brumme Chanson J, Gatanaga Hiroyuki, Gatanag Hiroyuki, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
BACKGROUND: HLA class I-associated escape mutations in HIV-1 Gag can reduce viral replication, suggesting that associated fitness costs could impact HIV-1 disease progression. Previous studies in North American and African cohorts have reported reduced Gag-Protease mediated viral replication capacity (Gag-Pro RC) in individuals expressing protective HLA class I alleles including HLA-B*57:01, B*27:05, and B*81:01....
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