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Article

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Journal of virology - 1 Apr 2006

Martinez-Picado Javier, Prado Julia G, Fry Elizabeth E, Pfafferott Katja, Leslie Alasdair, Chetty Senica, Thobakgale Christina, Honeyborne Isobel, Crawford Hayley, Matthews Philippa, Pillay Tilly, Rousseau Christine, Mullins James I, Brander Christian, Walker Bruce D, Stuart David I, Kiepiela Photini, Goulder Philip

Abstract excerpt

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may carry a sufficient cost to viral replicative capacity to facilitate subsequent immune control of a now attenuated virus. In order to examine how limitations can be imposed on viral escape, the epitope TSTLQEQIGW (TW10...

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Share to Capsid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Core Protein p24

Share to HLA-B Antigens

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Share to Infectious Disease Transmission, Vertical

Share to Sequence Analysis, Protein

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 16537629
DOI: 10.1128/JVI.80.7.3617-3623.2006
PMCID: PMC1440414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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