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Article

Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.

PLoS computational biology - 1 Jan 2012

Mostowy Rafal, Kouyos Roger D, Hoof Ilka, Hinkley Trevor, Haddad Mojgan, Whitcomb Jeannette M, Petropoulos Christos J, Keşmir Can, Bonhoeffer Sebastian

Abstract excerpt

Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral peptides to human leukocyte antigen (HLA) molecule...

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Share to Adaptation, Physiological
Share to Computer Simulation
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease

Share to HIV Reverse Transcriptase

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Source

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Identifiers

PMID: 22654656
DOI: 10.1371/journal.pcbi.1002525
PMCID: PMC3359966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22654656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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