Article
Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity.
Proteins - 1 May 2001
Beyer B M, Zhang R, Hong Z, Madison V, Malcolm B A
Abstract excerpt
A comparison of the DNA sequences from all available genotypes of HCV indicate that the active site residues of the NS3 protease are strictly conserved with the exception of positions 123 and 168, which border the S(4) subsite. In genotype 3, the canonic arginine and aspartic acid have been replaced with threonine and glutamine, respectively. To determine if these differences contribute to an altered specificity,...
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