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Article

Relation between viral fitness and immune escape within the hepatitis C virus protease.

Gut - 1 Feb 2006

Söderholm J, Ahlén G, Kaul A, Frelin L, Alheim M, Barnfield C, Liljeström P, Weiland O, Milich D R, Bartenschlager R, Sällberg M

Abstract excerpt

BACKGROUND: The hepatitis C virus (HCV) mutates within human leucocyte antigen (HLA) class I restricted immunodominant epitopes of the non-structural (NS) 3/4A protease to escape cytotoxic T lymphocyte (CTL) recognition and promote viral persistence. However, variability is not unlimited, and sometimes almost absent, and factors that restrict viral variability have not been defined experimentally. AIMS: We wished...

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Share to T-Lymphocytes, Cytotoxic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Epitopes, T-Lymphocyte

Share to HLA-A2 Antigen

Share to Immune Tolerance

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Source

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Identifiers

PMID: 16105887
DOI: 10.1136/gut.2005.072231
PMCID: PMC1856491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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