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Article

Changing Selective Pressure during Antigenic Changes in Human Influenza H3

1 May 2008

Abstract excerpt

The rapid evolution of influenza viruses presents difficulties in maintaining the optimal efficiency of vaccines. Amino acid substitutions result in antigenic drift, a process whereby antisera raised in response to one virus have reduced effectiveness against future viruses. Interestingly, while amino acid substitutions occur at a relatively constant rate, the antigenic properties of H3 move in a discontinuous,...

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PMID: 18451985
DOI: 10.1371/journal.ppat.1000058

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