Article
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.
Science (New York, N.Y.) - 22 Nov 2013
Koel Björn F, Burke David F, Bestebroer Theo M, van der Vliet Stefan, Zondag Gerben C M, Vervaet Gaby, Skepner Eugene, Lewis Nicola S, Spronken Monique I J, Russell Colin A, Eropkin Mikhail Y, Hurt Aeron C, Barr Ian G, de Jong Jan C, Rimmelzwaan Guus F, Osterhaus Albert D M E, Fouchier Ron A M, Smith Derek J
Abstract excerpt
The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was caused mainly by single amino acid substitutions, which occurred at only seven positions in HA immediately adjacent to the receptor binding site. Most of these substitutions were involved in antigenic change more than once. Equivalent positions were responsible...
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