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Article

The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.

The Journal of allergy and clinical immunology - 1 Aug 2012

Hawkins Gregory A, Robinson Mac B, Hastie Annette T, Li Xingnan, Li Huashi, Moore Wendy C, Howard Timothy D, Busse William W, Erzurum Serpil C, Wenzel Sally E, Peters Stephen P, Meyers Deborah A, Bleecker Eugene R

Abstract excerpt

BACKGROUND: The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity. The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes...

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Identifiers

PMID: 22554704
DOI: 10.1016/j.jaci.2012.03.018
PMCID: PMC3409329

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FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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