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Article

Association of the STAT-6 rs324011 (C2892T) variant but not rs324015 (G2964A), with atopic asthma in a Saudi Arabian population.

Human immunology - 1 Aug 2014

Al-Muhsen Saleh, Vazquez-Tello Alejandro, Jamhawi Amer, Al-Jahdali Hamdan, Bahammam Ahmed, Al Saadi Muslim, Iqbal Shaikh Mohammed, Alfrayh Abdulrahman, Afzal Sibtain, Al-Khamis Nouf, Halwani Rabih

Abstract excerpt

BACKGROUND: The signal transducer and activator of transcription 6 (STAT6) transduces signals in response to IL-4 and IL-13 cytokine stimulations, resulting in many cell-specific responses. Some common STAT6 SNPs were associated with asthma predisposition and/or IgE levels, although discrepancies have also been reported. OBJECTIVE: To determine whether STAT6 rs324011 and rs324015 polymorphisms are associated with...

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PMID: 24912007
DOI: 10.1016/j.humimm.2014.05.012

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STAT6

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