Article
Genome-wide association study to identify genetic determinants of severe asthma.
Thorax - 1 Sept 2012
Wan Y I, Shrine N R G, Soler Artigas M, Wain L V, Blakey J D, Moffatt M F, Bush A, Chung K F, Cookson W O C M, Strachan D P, Heaney L, Al-Momani B A H, Mansur A H, Manney S, Thomson N C, Chaudhuri R, Brightling C E, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway J W, Howarth P H, Hui J, Musk A W, James A L, Brown M A, Baltic S, Ferreira M A R, Thompson P J, Tobin M D, Sayers I, Hall I P
Abstract excerpt
BACKGROUND: The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear. OBJECTIVE: To identify common genetic variants affecting susceptibility to severe asthma. METHODS: A genome-wide association study was undertaken in 933 European ancestry individuals with...
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