Article
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
Lancet (London, England) - 10 Sept 2011
Ferreira Manuel A R, Matheson Melanie C, Duffy David L, Marks Guy B, Hui Jennie, Le Souëf Peter, Danoy Patrick, Baltic Svetlana, Nyholt Dale R, Jenkins Mark, Hayden Catherine, Willemsen Gonneke, Ang Wei, Kuokkanen Mikko, Beilby John, Cheah Faang, de Geus Eco J C, Ramasamy Adaikalavan, Vedantam Sailaja, Salomaa Veikko, Madden Pamela A, Heath Andrew C, Hopper John L, Visscher Peter M, Musk Bill, Leeder Stephen R, Jarvelin Marjo-Riitta, Pennell Craig, Boomsma Dorret I, Hirschhorn Joel N, Walters Haydn, Martin Nicholas G, James Alan, Jones Graham, Abramson Michael J, Robertson Colin F, Dharmage Shyamali C, Brown Matthew A, Montgomery Grant W, Thompson Philip J
Abstract excerpt
BACKGROUND: We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease. METHODS: We did a genome-wide association study (GWAS) in 2669 physician-diagnosed asthmatics and 4528 controls from Australia. Seven loci were prioritised for replication after combining our results with those from the GABRIEL consortium...
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