The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

doi:10.1007/s10519-014-9656-8

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Article

The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

Behavior genetics - 1 Jul 2014

van Dongen Jenny, Jansen Rick, Smit Dirk, Hottenga Jouke-Jan, Mbarek Hamdi, Willemsen Gonneke, Kluft Cornelis, Penninx Brenda W J, Ferreira Manuel A, Boomsma Dorret I, de Geus Eco J C

Abstract excerpt

The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide range of common diseases, including asthma, rheumatoid arthritis, type 1 diabetes and coronary heart disease. We examined the contribution of this functional IL6R gene polymorphism rs2228145 versus ot...

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Identifiers

PMID: 24791950
DOI: 10.1007/s10519-014-9656-8
PMCID: PMC4283105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24791950-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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