Article
A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.
Genes and immunity - 1 Oct 2013
Revez J A, Bain L, Chapman B, Powell J E, Jansen R, Duffy D L, Tung J Y, Penninx B W, Visscher P M, De Geus E J C, Boomsma D I, Hinds D A, Martin N G, Montgomery G W, Ferreira M A R
Abstract excerpt
The main genetic determinant of soluble interleukin 6 receptor (sIL-6R) levels is the missense variant rs2228145 that maps to the cleavage site of IL-6R. For each Ala allele, sIL-6R serum levels increase by ≈ 20 ng ml(-1) and asthma risk by 1.09-fold. However, this variant does not explain the total heritability for sIL-6R levels. Additional independent variants in IL6R may therefore contribute to variation in...
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