Article
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.
PLoS genetics - 1 Apr 2013
Ferreira Ricardo C, Freitag Daniel F, Cutler Antony J, Howson Joanna M M, Rainbow Daniel B, Smyth Deborah J, Kaptoge Stephen, Clarke Pamela, Boreham Charlotte, Coulson Richard M, Pekalski Marcin L, Chen Wei-Min, Onengut-Gumuscu Suna, Rich Stephen S, Butterworth Adam S, Malarstig Anders, Danesh John, Todd John A
Abstract excerpt
Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the etiology of several chronic diseases. Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.