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Article

IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes.

PloS one - 1 Jan 2026

Kanoksing Pattara, Puangpetch Apichaya, Kawamatawong Theerasuk, Kuttiyod Thatchathum, Simmalee Kantapat, Frutos Roger, Lumjiaktase Putthapoom

Abstract excerpt

Type 2-high airway inflammation in adults with asthma is heavily driven by the cytokines interleukin (IL)-4, IL-5, and IL-13. While genetic variations in these cytokines are known to influence asthma pathogenesis, their specific impacts on clinically relevant phenotypes remain to be fully elucidated. This study aimed to investigate the associations between inflammatory cytokine gene polymorphisms, clinical asthma...

Topics

Humans
Asthma
Interleukin-13
Female
Polymorphism, Single Nucleotide
Male
Interleukin-5
Adult
Phenotype
Middle Aged
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Eosinophils

Genetic Predisposition to Disease

Immunoglobulin E

Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 42497191
DOI: 10.1371/journal.pone.0354597
PMCID: PMC13399323

Genes

IL13
IL5
IL4
IL33
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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