Article
A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk.
Scientific reports - 2 Apr 2022
Chang Diana, Hunkapiller Julie, Bhangale Tushar, Reeder Jens, Mukhyala Kiran, Tom Jennifer, Cowgill Amy, Vogel Jan, Forrest William F, Khan Zia, Stockwell Amy, McCarthy Mark I, Staton Tracy L, Olsson Julie, Holweg Cecile T J, Cheung Dorothy S, Chen Hubert, Brauer Matthew J, Graham Robert R, Behrens Timothy, Wilson Mark S, Arron Joseph R, Choy David F, Yaspan Brian L
Abstract excerpt
Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics underlying moderate-to-severe asthma risk. Here, we present a whole-genome sequencing study comparing 3181 moderate-to-severe asthma patients to 3590 non-asthma controls. We demonstrate that asthma risk is genetically correlated with lung function measures...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.