Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.

Cancer cell - 1 Nov 2002

Roberts Charles W M, Leroux Monique M, Fleming Mark D, Orkin Stuart H

Abstract excerpt

Recent data suggest the SWI/SNF chromatin remodeling complex may also act as a tumor suppressor. Utilizing a reversibly inactivating conditional allele, we demonstrate that loss of Snf5/Ini1/Baf47/SmarcB1, a core subunit of SWI/SNF, results in highly penetrant cancer predisposition with 100% of m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Chromosomal Proteins, Non-Histone
Share to Chromosome Inversion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Lymphoma, T-Cell

Share to Penetrance

Share to Rhabdoid Tumor

Share to SMARCB1 Protein

Source

Identifiers

PMID: 12450796
DOI: 10.1016/s1535-6108(02)00185-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12450796-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.PMID 12450796Read ↗

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.Semantic proximity Read ↗

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.Semantic proximity Read ↗

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.Semantic proximity Read ↗

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.Semantic proximity Read ↗

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumorsSemantic proximity Read ↗

Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53Semantic proximity Read ↗

Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.Semantic proximity Read ↗

Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.Semantic proximity Read ↗

Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex.Semantic proximity Read ↗

Loss of Snf5 Induces Formation of an Aberrant SWI/SNF ComplexSemantic proximity Read ↗

SWI/SNF chromatin remodeling complexes and cancer.Semantic proximity Read ↗

SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.