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Article

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

Molecular and cellular biology - 1 Oct 2008

McKenna Elizabeth S, Sansam Courtney G, Cho Yoon-Jae, Greulich Heidi, Evans Julia A, Thom Christopher S, Moreau Lisa A, Biegel Jaclyn A, Pomeroy Scott L, Roberts Charles W M

Abstract excerpt

There is a growing appreciation of the role that epigenetic alterations can play in oncogenesis. However, given the large number of genetic anomalies present in most cancers, it has been difficult to evaluate the extent to which epigenetic changes contribute to cancer. SNF5 (INI1/SMARCB1/BAF47) is a tumor suppressor that regulates the epigenome as a core member of the SWI/SNF chromatin remodeling complex. While...

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Identifiers

PMID: 18710953
DOI: 10.1128/MCB.00658-08
PMCID: PMC2577431

Genes

SMARCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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