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Article

Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex

1 Feb 2017

Abstract excerpt

The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoid cancers. We examined the effects of Snf5 loss on the composition, nucleosome binding, recruitment, and remodeling activities of yeast SWI/SNF. The Snf5 subunit is shown by...

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PMID: 28249160
DOI: 10.1016/j.celrep.2017.02.017

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