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Article

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development

10 Jul 2014

Abstract excerpt

UNLABELLED: Malignant rhabdoid tumors (MRT), a pediatric cancer that most frequently appears in the kidney and brain, generally lack SNF5 (SMARCB1/INI1), a subunit of the SWI/SNF chromatin-remodeling complex. Recent studies have established that multiple SWI/SNF complexes exist due to the presence or absence of different complex members. Therefore, the effect of SNF5 loss upon SWI/SNF complex formation was...

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PMID: 25009291
DOI: 10.1158/1541-7786.mcr-14-0005

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