Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2000

Roberts C W, Galusha S A, McMenamin M E, Fletcher C D, Orkin S H

Abstract excerpt

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80% of affected children die, often within 1 year of diagnosis. The majority of MRT samples and cell li...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to Cloning, Molecular
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Mice, Knockout

Share to Rhabdoid Tumor

Share to Sequence Homology, Amino Acid

Share to SMARCB1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 11095756
DOI: 10.1073/pnas.250492697
PMCID: PMC17655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11095756-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.PMID 11095756Read ↗

Integrase interactor 1 in health and disease.Semantic proximity Read ↗

Molecular genetics of atypical teratoid/rhabdoid tumor.Semantic proximity Read ↗

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.Semantic proximity Read ↗

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor DevelopmentSemantic proximity Read ↗

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumorsSemantic proximity Read ↗

Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53Semantic proximity Read ↗

Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid TumorsSemantic proximity Read ↗

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.Semantic proximity Read ↗

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.Semantic proximity Read ↗

Establishment and characterization of MRT cell lines from genetically engineered mouse models and the influence of genetic background on their development.Semantic proximity Read ↗

<i>Aurora A</i> Is a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell SurvivalSemantic proximity Read ↗

Hereditary SWI/SNF complex deficiency syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.