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Article

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2000

Roberts C W, Galusha S A, McMenamin M E, Fletcher C D, Orkin S H

Abstract excerpt

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80% of affected children die, often within 1 year of diagnosis. The majority of MRT samples and cell lines have sustained biallelic inactivating mutations of the hSNF5 (integrase interactor 1) gene, suggesting that hSNF5...

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Source

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Identifiers

PMID: 11095756
DOI: 10.1073/pnas.250492697
PMCID: PMC17655

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