Article
Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.
RNA (New York, N.Y.) - 1 Jun 2012
Forconi Marcello, Benz-Moy Tara, Gleitsman Kristin Rule, Ruben Eliza, Metz Clyde, Herschlag Daniel
Abstract excerpt
Atomic mutagenesis has emerged as a powerful tool to unravel specific interactions in complex RNA molecules. An early extensive study of analogs of the exogenous guanosine nucleophile in group I intron self-splicing by Bass and Cech demonstrated structure-function relationships analogous to those seen for protein ligands and provided strong evidence for a well-formed substrate binding site made of RNA. Subsequent...
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