Article

Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?

2016-06-27

Abstract excerpt

Since the discovery of the first catalytic RNA in 1981, the field of ribozyme research has developed from the discovery of catalytic RNA motifs in nature and the elucidation of their structures and catalytic mechanisms, into a field of engineering and design towards application in diagnostics, molecular biology and medicine. Owing to the development of powerful protocols for selection of nucleic acid catalysts wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2551b71e-1b5a-5ce5-9338-1af914ef79bb
DOI: 10.12688/f1000research.8601.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?DOI 10.12688/f1000research.8601.1Read

Getting a DNA to do an RNA's job.Semantic proximity Read

High-Throughput Analysis and Engineering of Ribozymes and Deoxyribozymes by Sequencing.Semantic proximity Read

Ribozyme-catalyzed transcription of an active ribozyme.Semantic proximity Read

Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection.Semantic proximity Read

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity.Semantic proximity Read

Ribozyme gene therapy: applications for molecular medicine.Semantic proximity Read

RNA structure. Ribozyme evolution at the crossroads.Semantic proximity Read

Searching genomes for ribozymes and riboswitches.Semantic proximity Read

Rational design of allosteric ribozymes.Semantic proximity Read

Three critical hydrogen bonds determine the catalytic activity of the Diels-Alderase ribozyme.Semantic proximity Read

Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease GenesSemantic proximity Read

Is your ribozyme design really correct?: A proposal of simple single turnover competition assay to evaluate ribozymes.Semantic proximity Read