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Article

Defining the chemical groups essential for Tetrahymena group I intron function by nucleotide analog interference mapping.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997

Strobel S A, Shetty K

Abstract excerpt

Improved atomic resolution biochemical methods are needed to identify the chemical groups within an RNA that are essential to its activity. As a step toward this goal, we report the use of 5'-O-(1-thio)inosine monophosphate (IMP alphaS) in a nucleotide analog interference mapping (NAIM) assay that makes it possible to simultaneously, yet individually, determine the contribution of almost every N2 exocyclic amine...

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Identifiers

PMID: 9096319
DOI: 10.1073/pnas.94.7.2903
PMCID: PMC20295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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