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Article

Evolution of Tetrahymena ribozyme mutants with increased structural stability.

Nature structural biology - 1 Nov 2002

Guo Feng, Cech Thomas R

Abstract excerpt

Determining how large RNA molecules stabilize their tertiary structures is critical for understanding how they perform their biological functions. Here we use in vitro selection to identify active variants of the Tetrahymena ribozyme with increased stability. The mutant pool converged to a single family that shared nine mutations; an RNA representing the consensus sequence was structurally more stable by 10.5...

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Identifiers

PMID: 12368901
DOI: 10.1038/nsb850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolution of Tetrahymena ribozyme mutants with increased structural stability.PMID 12368901Read ↗

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Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution.Semantic proximity Read ↗

In vitro genetic analysis of the Tetrahymena self-splicing intron.Semantic proximity Read ↗

Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

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