Article
Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity.
Nature structural biology - 1 Sept 2003
Khvorova Anastasia, Lescoute Aurélie, Westhof Eric, Jayasena Sumedha D
Abstract excerpt
The hammerhead ribozyme (HHRz) is a small, naturally occurring ribozyme that site-specifically cleaves RNA and has long been considered a potentially useful tool for gene silencing. The minimal conserved HHRz motif derived from natural sequences consists of three helices that intersect at a highly conserved catalytic core of 11 nucleotides. The presence of this motif is sufficient to support cleavage at high Mg2+...
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