Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.

Journal of biochemistry - 1 Nov 2002

Ohki Yasushi, Ikawa Yoshiya, Shiraishi Hideaki, Inoue Tan

Abstract excerpt

The Tetrahymena group I intron ribozyme folds into a complex three dimensional structure for performing the self-splicing reaction. Catalysis depends on its core structure comprising two helical domains, P4-P6 and P3-P7. The two domains are joined by three sets of conserved base-triple(s) and other tertiary interactions. We found that the disruption of J8/7 X P4, one such conserved base-triple, causes the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Conserved Sequence
Share to Introns

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Nucleic Acid Conformation

Share to RNA, Catalytic

Share to Tetrahymena

Source

Identifiers

PMID: 12417020
DOI: 10.1093/oxfordjournals.jbchem.a003278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.PMID 12417020Read ↗

An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.Semantic proximity Read ↗

Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.Semantic proximity Read ↗

A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect.Semantic proximity Read ↗

The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Semantic proximity Read ↗

The effect of long-range loop-loop interactions on folding of the Tetrahymena self-splicing RNA.Semantic proximity Read ↗

Evolution of Tetrahymena ribozyme mutants with increased structural stability.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.Semantic proximity Read ↗

Installation of orthogonality to the interface that assembles two modular domains in the Tetrahymena group I ribozyme.Semantic proximity Read ↗

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Semantic proximity Read ↗

A 3' splice site-binding sequence in the catalytic core of a group I intron.Semantic proximity Read ↗

P2 functions as a spacer in the Tetrahymena ribozyme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.