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Article

Substitution of an essential adenine in the U1A-RNA complex with a non-polar isostere.

Nucleic acids research - 1 Dec 2002

Tuite Jacob B, Shiels Jerome C, Baranger Anne M

Abstract excerpt

The RNA recognition motif (RRM) binds to single-stranded RNA target sites of diverse sequences and structures. A conserved mode of base recognition by the RRM involves the simultaneous formation of a network of hydrogen bonds with the base functional groups and a stacking interaction between the base and a highly conserved aromatic amino acid. We have investigated the energetic contribution of the functional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12466552
DOI: 10.1093/nar/gkf636
PMCID: PMC137951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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