Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.

Abstract excerpt

Riboswitches are conserved functional domains in mRNA that mostly exist in bacteria. They regulate gene expression in response to varying concentrations of metabolites or metal ions. Recently, the NMT1 RNA motif has been identified to selectively bind xanthine and uric acid, respectively, both are involved in the metabolic pathway of purine degradation. Here, we report a crystal structure of this RNA bound to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Cations, Divalent
• Share to Crystallography, X-Ray