Article
An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999
Szewczak A A, Ortoleva-Donnelly L, Zivarts M V, Oyelere A K, Kazantsev A V, Strobel S A
Abstract excerpt
Key to understanding the structural biology of catalytic RNA is determining the underlying networks of interactions that stabilize RNA folding, substrate binding, and catalysis. Here we demonstrate the existence and functional importance of a Hoogsteen base triple (U300.A97-U277), which anchors the substrate helix recognition surface within the Tetrahymena group I ribozyme active site. Nucleotide analog...
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