Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect.

RNA (New York, N.Y.) - 1 Nov 2004

Karbstein Katrin, Tang Kuo-Hsiang, Herschlag Daniel

Abstract excerpt

Previous work on group I introns has suggested that a central base triple might be more important for the first rather than the second step of self-splicing, leading to a model in which the base triple undergoes a conformational change during self-splicing. Here, we use the well-characterized L-21 ScaI ribozyme derived from the Tetrahymena group I intron to probe the effects of base-triple disruption on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Conserved Sequence
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA, Catalytic

Share to RNA, Protozoan

Share to RNA Splicing

Share to Tetrahymena

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 15496521
DOI: 10.1261/rna.7118104
PMCID: PMC1370661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect.PMID 15496521Read ↗

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.Semantic proximity Read ↗

Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.Semantic proximity Read ↗

An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.Semantic proximity Read ↗

Two universally conserved adenosines of the group I intron that are important for self-splicing but not for core catalytic activity.Semantic proximity Read ↗

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Semantic proximity Read ↗

Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.Semantic proximity Read ↗

Folding pathways of the Tetrahymena ribozyme.Semantic proximity Read ↗

Base pairing between the 3' exon and an internal guide sequence increases 3' splice site specificity in the Tetrahymena self-splicing rRNA intron.Semantic proximity Read ↗

Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.Semantic proximity Read ↗

Requirements of a group I intron for reactions at the 3' splice site.Semantic proximity Read ↗

Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution.Semantic proximity Read ↗

Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.