Article
In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure (London, England : 1993) - 4 Sept 2018
Shoffner Grant M, Wang Ruixuan, Podell Elaine, Cech Thomas R, Guo Feng
Abstract excerpt
Crystallography is a major technique for determining large RNA structures. Obtaining diffraction-quality crystals has been the bottleneck. Although several RNA crystallization methods have been developed, the field strongly needs additional approaches. Here we invented an in crystallo selection strategy for identifying mutations that enhance a target RNA's crystallizability. The strategy includes constructing an...
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