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Article

Essential functions of C terminus of Drosophila Topoisomerase IIIα in double holliday junction dissolution.

The Journal of biological chemistry - 1 Jun 2012

Chen Stefanie Hartman, Wu Chung-Hsuan, Plank Jody L, Hsieh Tao-shih

Abstract excerpt

Topoisomerase IIIα (Top3α) is an essential component of the double Holliday junction (dHJ) dissolvasome complex in metazoans, along with Blm and Rmi1/2. This important anti-recombinogenic function cannot be performed by Top3β, the other type IA topoisomerase present in metazoans. The two share a catalytic core but diverge in their tail regions. To understand this difference in function, we investigated the role...

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Identifiers

PMID: 22511792
DOI: 10.1074/jbc.M112.363044
PMCID: PMC3365971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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