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Article

Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010

Wu Jianhong, Feng Liping, Hsieh Tao-shih

Abstract excerpt

Topoisomerase IIIalpha (topo IIIalpha), a member of the conserved Type IA subfamily of topoisomerases, is required for the cell proliferation in mitotic tissues, but has a lesser effect on DNA endoreplication. The top3alpha gene encodes two forms of protein by utilizing alternative translation initiation sites: one (short form) with the nuclear localization signal only, exclusively localized in the nuclei, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20308575
DOI: 10.1073/pnas.1001855107
PMCID: PMC2852012

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