Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.

The Journal of biological chemistry - 26 Oct 2007

Bussen Wendy, Raynard Steven, Busygina Valeria, Singh Akhilesh K, Sung Patrick

Abstract excerpt

BLM, the protein mutated in Bloom's syndrome, possesses a helicase activity that can dissociate DNA structures, including the Holliday junction, expected to arise during homologous recombination. BLM is stably associated with topoisomerase IIIalpha (Topo IIIalpha) and the BLAP75 protein. The BLM-Topo IIIalpha-BLAP75 (BTB) complex can efficiently resolve a DNA substrate that harbors two Holliday junctions (the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bloom Syndrome

Share to DNA Helicases

Share to DNA Topoisomerases, Type I

Share to Histidine

Share to Hydrolysis

Share to RecQ Helicases

Source

Identifiers

PMID: 17728255
DOI: 10.1074/jbc.M706116200

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.PMID 17728255Read ↗

A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.Semantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.Semantic proximity Read ↗

Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.Semantic proximity Read ↗

The BLM dissolvasome in DNA replication and repair.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Aberrant chromosome morphology in human cells defective for Holliday junction resolution.Semantic proximity Read ↗

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.Semantic proximity Read ↗

Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.Semantic proximity Read ↗

Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.Semantic proximity Read ↗

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.