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Article

Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition.

The Biochemical journal - 1 May 2008

Laco Gary S, Pommier Yves

Abstract excerpt

Human Top1 (topoisomerase I) relaxes supercoiled DNA during cell division and transcription. Top1 is composed of 765 amino acids and contains an unstructured N-terminal domain of 200 amino acids, and a structured functional domain of 565 amino acids that binds and relaxes supercoiled DNA. In the present study we examined the region spanning the junction of the N-terminal domain and functional domain (junction...

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Identifiers

PMID: 18215123
DOI: 10.1042/BJ20071436
PMCID: PMC2692499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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