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Article

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Wu Leonard, Bachrati Csanad Z, Ou Jiongwen, Xu Chang, Yin Jinhu, Chang Michael, Wang Weidong, Li Lei, Brown Grant W, Hickson Ian D

Abstract excerpt

BLM encodes a member of the highly conserved RecQ DNA helicase family, which is essential for the maintenance of genome stability. Homozygous inactivation of BLM gives rise to the cancer predisposition disorder Bloom's syndrome. A common feature of many RecQ helicase mutants is a hyperrecombinati...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16537486
DOI: 10.1073/pnas.0508295103
PMCID: PMC1449647

Genes

BLM
RMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16537486-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.PMID 16537486Read ↗

A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.Semantic proximity Read ↗

The BLM dissolvasome in DNA replication and repair.Semantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.Semantic proximity Read ↗

Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.Semantic proximity Read ↗

Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.Semantic proximity Read ↗

Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.Semantic proximity Read ↗

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsSemantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resectionSemantic proximity Read ↗

RecQ helicases: guardian angels of the DNA replication fork.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

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