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Article

Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development.

The Journal of biological chemistry - 4 Feb 2005

Plank Jody L, Chu Shin Hai, Pohlhaus Jennifer Reineke, Wilson-Sali Tina, Hsieh Tao-Shih

Abstract excerpt

Eukaryotic type IA topoisomerases are important for the normal function of the cell, and in some cases essential for the organism, although their role in DNA metabolism remains to be elucidated. In this study, we cloned Drosophila melanogaster topoisomerase (topo) IIIalpha from an embryonic cDNA...

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PMID: 15537633
DOI: 10.1074/jbc.M411337200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15537633-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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